International Archives of Medical and Health Research (IAMHR), pISSN: 2705-1420; eISSN: 2705-1439 
September to October 2019 Vol 1(3): pp.89-93    DOI: https://doi.org/10.33515/iamhr/2019.026/26

Copyright © 2019 C-International Archives

Original Article

Comparative in-vivo anxiolytic efficacy of aqueous and methanol Tapinanthus globiferus leaf extracts

Ajibola M. Umarudeen1*, Garba M. Magaji2

1Department of Pharmacology & Therapeutics, University of Abuja, Abuja, Nigeria

2Department of Pharmacology & Therapeutics, Ahmadu Bello University, Zaria, Nigeria

 

*Corresponding Author’s Email: umarudeen.monisola@uniabuja.edu.ng

 

Published November 28, 2019

 


ABSTRACT

Anxiety disorders have been known to be highly prevalent and to exert heavy disease burden on the health delivery system. The increasing prevalence is not helped by the fewness and individual drawbacks of the currently prescribed anxiolytic drugs. This situation calls for discovery of new anxiolytic agents. This study investigated the in-vivo anxiolytic efficacy of intraperitoneal injection of 50, 150 and 500 mg/kg aqueous and methanol leaf extracts of T. globiferus, 0.5 mg/kg diazepam and 10 ml/kg distilled water in mice using standard test battery of open-field and elevated zero-maze tests. While treatment with the aqueous Tapinanthus globiferus leaf extract caused significant (p<0.05) alterations compared to the negative control in all the four rodent anxiety parameters evaluated which comprised percentage centre zone time (%CZT), rears, percentage open segment time (%OST) and unprotected head dips (UHDs); its methanol counterpart only caused significant alterations in only three parameters which comprised percentage centre zone time (%CZT), rears, percentage open segment time (%OST).  Overall, these results indicate though both aqueous and methanol leaf extracts of T. globiferus grown on Azadirachta indica possess anxiolytic effects, the former however, exhibited superior anxiolytic potency over the latter and these extracts need be developed further for potential anxiety-alleviation use.

 

Keywords: In-vivo, anxiolytic efficacy, Tapinanthus globiferus, test battery, mice, optimization 

 

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