International Archives of Medicine and Medical Sciences (IAMMS), pISSN: 2705-1404; eISSN: 2705-1412
November to December 2019 Vol 1(3): pp.29-34    DOI: https://doi.org/10.33515/iamms/2019.031/31

Copyright © 2019 C-International Archives

Original Article

Phytochemical, elemental and in-vitro anti-oxidant activity screening of crude methanol Tapinanthus globiferus leaf extract

Ajibola M. Umarudeen1*, Aminu Chika2

1Department of Pharmacology & Therapeutics, University of Abuja, Abuja, Nigeria

2Department of Pharmacology & Therapeutics, Usmanu Danfodiyo University, Sokoto, Nigeria

*Corresponding Author’s Email: umarudeen.monisola@uniabuja.edu.ng

 

Published December 31, 2019


ABSTRACT

Tapinanthus species have been reported with safe toxicity profiles and efficacy in several categories of diseases. Their ethnobotanical/pharmacological activities are viewed to be related to their phytochemical and elemental constituents as well as their anti-oxidant activity. This study carried out phytochemical, elemental and in-vitro anti-oxidant activity screening on crude methanol Tapinanthus globiferus leaf extract. Flavonoids, terpenoids, phenols, alkaloids, saponins, tannin, cardiac glycosides and carbohydrates but not anthraquinones were found in the leaf extract. Cadmium, copper, iron, manganese, sodium, potassium, calcium but not lead and cobalt were present in the extract. The extract also demonstrated dose-dependent ferric ion reducing and α, α-diphenyl-β-picrylhydrazyl (DPPH) free radicals scavenging anti-oxidant activities that were inferior to those of the standard anti-oxidant (ascorbic acid). Some of the phytochemicals and the metal elements may be responsible for the anti-oxidant activity of this extract and for the reported ethnobotanical/pharmacological efficacies of Tapinanthus globiferus extracts.

Keywords: Tapinanthus globiferus, oxidative stress, ferric ion reducing, DPPH radical scavenging

 

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