iamms/2019.032/32/kareem et al. – C-International Archives

International Archives of Medicine and Medical Sciences (IAMMS), pISSN: 2705-1404; eISSN: 2705-1412
November to December 2019 Vol 1(3): pp.35-41 DOI: https://doi.org/10.33515/iamms/2019.032/32

Original Article

Evaluation of hypoglycemic and hypolipidemic effects of aqueous Eleusine coracana seed extract

Adepoju M. Kareem ^1*, Shuaibu O. Bello², Emmanuel Etuk², Sarafadeen A. Arisegi¹, Muhammad T. Umar²

¹Department of Family Medicine, Usmanu Danfodiyo University Teaching Hospital, Sokoto, Nigeria

²Department of Pharmacology & Therapeutics, Usmanu Danfodiyo University, Sokoto, Nigeria

*Corresponding Author’s Email: adekareem4@gmail.com

Published December 31, 2019

ABSTRACT

Patients with diabetes mellitus almost always have secondary hyperlipidemia which requires tight control of the blood glucose level with drugs. Eleusine coracana (EC) is widely used in northwestern Nigeria for the treatment of diabetes by traditional healers who consider it to be effective and safe. This study evaluated the hypoglycemic and hypolipidemic effects of Eleusine coracana seed extract in alloxan-induced hyperglycemic Wistar rats. All the doses of EC prevented a sustained increase in the blood glucose level after glucose loading. The antihyperglycemic effect was dose dependent and reached a maximum level at 120 and 180 minutes, and there was a significant reduction in blood glucose level in all the treated groups as compared to the normal control and metformin diabetic control groups. There were steady reductions in the levels of serum triglycerides (TG’s) and high density lipoprotein (HDL) in a dose dependent pattern in the treated group as compared to the metformin diabetic control group. EC extract also reduced serum triglycerides (TG’s) and high density lipoprotein (HDL) in all the doses tested. This study has shown that aqueous Eleusin coracana seed extract remarkably reduced serum blood glucose level in both normal and alloxan-induced diabetic rats at the studies doses. Furthermore, the extract showed a significant hypolipidemic effect with decreases in serum total cholesterol and low density lipoprotein levels. These findings showed that EC seed extract has therapeutic potential in combating the multi factorial disorders which are a part of the major complications of diabetes, and further studies should be conducted to determine the mechanism of the action of its hypoglycemic and hypolipidemic effects.

Keywords: Eleusine coracana, hypoglycemic and hypolipidemic effects

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