Background: The perennial inadequate electricity supply in Nigeria has become a serious threat to the economic development of the country, and a major driving force behind the proliferation of fossil fuel generator as an alternative source of energy for both domestic and commercial purposes across the country. Aim: This study aimed to assess the prevalence, knowledge of hazards and practices regarding generator use among small-scale business operators in Sokoto, Nigeria. Materials and Methods: This was a cross-sectional study among 285 small-scale business operators selected by a multistage sampling technique. A structured self-administered questionnaire was used to collect data on the research variables. Data were analyzed using the IBM SPSS version 20 statistical computer software package. Results: The mean age of respondents was 28.59 ± 7.09 years; most of them were males (80.4%) and have worked for ≤ 10 years (91.9%). Majority, 212 (74.4%) of the 285 respondents use fossil fuel generator as an alternative source of energy to run their businesses. Despite high levels of good knowledge of the hazards of generator use (73.7%) and the methods of preventing exposure to them (94.7%), practices related to exposure to the hazards were very prevalent among the respondents. Conclusion: This study showed high prevalence of generator use and practices related to exposure to its hazards among small-scale business operators in Sokoto, Nigeria, despite good knowledge of the hazards and the methods of preventing exposure to them. The Nigerian government should provide adequate and regular electricity supply across the country.